Exploring the Efficacy of Longevity Supplements

Longevity supplements aim to extend life and healthspan. While some evidence supports their benefits, research is ongoing. It's crucial to discern between scientifically backed compounds and unproven claims.

NAD+ is vital for cellular health. Precursors like NMN and NR could boost NAD+ levels, possibly slowing aging-related decline. Initial studies are promising, but conclusive human trials are needed.

Resveratrol, found in grapes, is touted for activating sirtuins, proteins linked to longevity. However, its effectiveness and bioavailability in humans remain under debate, with mixed results from studies.

Originally an immunosuppressant, rapamycin has shown lifespan extension in mice. Its mTOR inhibition may mimic caloric restriction, a known longevity factor. Human applications are speculative and require more research.

Metformin, a diabetes medication, may have anti-aging properties. It appears to influence metabolic and cellular processes associated with aging. The TAME trial is investigating its potential to delay age-related diseases.

Spermidine promotes autophagy, the process of cellular cleaning and renewal. This could theoretically prolong cell life. Dietary sources like wheat germ are beneficial, but supplemental effects require more study.

Polyphenols, common in fruits and vegetables, exhibit anti-inflammatory and antioxidant properties. They may improve longevity by protecting against chronic diseases. Diverse diet intake is recommended over supplements.