Prions: Definition
Prions are misfolded proteins causing neurodegenerative diseases. Unlike other pathogens, prions contain no nucleic acid, making them unique infectious agents.
Prion Disease Transmission
Transmission can occur through contaminated food, medical equipment, and certain medical procedures. Human-to-human transmission is rare but can happen through heredity.
Variants and Host Range
Prions cause various diseases, such as CJD in humans, BSE in cattle, and scrapie in sheep. Each variant tends to be species-specific, challenging cross-species barriers.
Symptoms and Progression
Prion diseases present with dementia, motor dysfunction, and ultimately death. They are progressive with no known cure, leading to severe brain damage.
Diagnosis of Prion Diseases
Diagnosing prion diseases is complex, involving MRI, cerebrospinal fluid tests, and sometimes brain tissue analysis after death for definitive confirmation.
Prion Resistance Mystery
Certain animals, like the camel, show unusual resistance to prion diseases. Studying these cases could reveal new approaches to treatment and prevention.
Potential Therapeutic Strategies
Research is exploring antibodies, RNA interference, and other compounds to halt prion replication. However, effective treatment remains elusive due to the prion's unconventional nature.
What are prions?
Infectious agents with nucleic acid
Misfolded proteins causing diseases
Bacteria affecting the nervous system
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