Beyond Cannabinoids: Exploring Mood Regulation

While cannabinoids affect mood, non-cannabinoid molecules, such as serotonergic and dopaminergic systems, play critical roles in mood regulation and mental health.

Serotonin impacts mood, anxiety, and happiness. SSRIs, by increasing serotonin levels, can alleviate depression, highlighting serotonin's significant role in mood regulation.

Dopamine is associated with pleasure and reward. Dysregulation can lead to mood disorders. Parkinson's disease, characterized by dopamine deficiency, often results in depression.

Brain-derived neurotrophic factor (BDNF) influences mood, cognition, and neuroplasticity. Low BDNF levels are linked to depression and anxiety, making it a target for new treatments.

The gut-brain axis suggests gut microbiota can affect mood. Certain bacteria produce neurotransmitters, like GABA, which can potentially modulate stress responses and emotional behavior.

Exercise increases BDNF levels and serotonin production, making it as effective as some antidepressants in improving mood and reducing anxiety.